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Usually because your dose or your concentration changed and the old barrel no longer fits it well
Safety Profile: Better Tolerability Than TRIUMPH-4 One of the most encouraging findings from TRIUMPH-1 is the discontinuation rate: 11.3%
doi:10.1056/NEJMoa2032183 Marso SP, Daniels GH, Brown-Frandsen K, et al
And pay attention to the Beyond-Use Date (BUD) printed on your vial, which is different from the expiration date and tells you how long the opened vial remains safe for multi-dose use
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